Capítulo 1..Linfocitos B.

  • Abul K. Abbas, Andrew H. Lichtman, Jordan S. Pober . Inmunología Celular y Molecular. cuarta edición.
  • Calame KL, Lin K-I and Tunyaplin C. Regulatory mechanisms that determine the development and function of plasma cells. Annual Review of Immunology 2003;21: 205–230.
  • Cyster JG . Homing of antibody secreting cells. Immunological Reviews 2003;194: 48–60.
  • Diamant E, Melamed D. Class switch recombination in B lymphopoiesis: a potential pathway for B cell autoimmunity. Autoimmun Rev. 2004, 3: 464-9.  
  • Edry E, Melamed D. Receptor editing in positive and negative selection of B lymphopoiesis. J Immunol. 2004, 173: 4265-71.
  • Guyton, Hall. Tratado de Fisiología Medica. Novena edición. Editorial MacGraw-Hill Interamericana. 1998.
  • Kurosaki T: Regulation of B cells signal transduction by adapter proteins. Nature Reviews Immunology 2002;2:354-363.
  • Neuberger, M. S.; Honjo, T.; Alt, Frederick W. Molecular biology of B cells. Amsterdam: Elsevier. 2004; pp.189–191.
  • Reece, Campbell. Biology , 7th Eddition. New York, Pearson Education, Inc. 2005
  • Regueiro JR, López Larrea C. Inmunología. Biología y Patología del Sistema Inmune (2ª Ed). Madrid, Editorial Médica Panamericana, 1997.
  • Slifka MK, Antia R, Whitmire JK and Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity 1998;8: 363–372.
  • Tew JG, DiLosa RM, Burton GF et al. Germinal centers and antibody production in bone marrow. Immunological Reviews 1992;126:99–112.
  • Thomas M. Devlin. Libro con Aplicaciones Clínicas. Tercera edición. Editorial Reverté, S.A. 1999.
  • Viau M, Zouali M. B-lymphocytes, innate immunity, and autoimmunity. Clin Immunol. 2005, 114: 17-26.
  • Villiers MB, Perrin-Cocon L, Marche PN, Villiers CL. Complement receptors and B lymphocytes. Crit Rev Immunol. 2004, 24: 465-78
  • Weil R, Israel A. T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappa B in lymphocytes. Curr Opin Immunol. 2004, 16: 374-81.

 

      Capitulo 2. Linfocitos T.

  • Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004, 40: 1295-305.
  • Call ME, Wucherpfennig KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol 2005;23:101-125.
  • Chatenoud L. CD3-specific antibodies restore self-tolerance: mechanisms and clinical applications. Curr Opin Immunol 2005; 17:632-637. 
  • Dahlke MH, Larsen SR, Rasko JE, Schlitt HJ. The biology of CD45 and its use as a therapeutic target. Leuk Lymphoma. 2004;45:229-36. 
  • Ford ML, Evavold BD. Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes. Mol Immunol. 2004, 40: 1019-25. 
  • Fundamentos de Inmunología e Inmunoquímica. Margni. Quinta edición. Editorial Panamericana. 1996.
  • Germain RN, Stefanova I. The dynamics of T cell receptor signaling: complex orchestration and the key role of tempo and cooperation. Annual Reviews of Immunology 1999;19: 467-522.
  • Gil D, Schrum AG, Alarcon B, Palmer E. T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J Exp Med 2005; 201:517-522. 
  • Grogan JA, Locksley RM. T helper cell differentiation: on again, off again. Current Opinion in Immunology 2002;14:366-372.
  • Isakov N, Altman A. Protein kinase C(theta) in T cell activation. Annu.Rev.Immunol 2002, 20:761-794.
  • Kappes DJ, Tonegawa S. Surface expression of alternative forms of the TCR/CD3 complex. Proc Natl Acad Sci USA 1991; 88:10619-10623.
  • Nakanishi,K.. Innate and acquired activation pathways in T cells. Nat.Immunol.2001;2:140-142.
  • Nemec,M. Web alert. Lymphocyte activation and effector functions. Curr. Opin. Immunol. 2001;265, 13:265.
  • Schatz,D.G. and Malissen,B.. Lymphocyte development. Curr. Opin. Immunol. 2002; 14:183-185.
  • Szabo SJ, Sullivan BM, Peng SL, Glimcher LH: Molecular mechanisms regulating TH1 immune responses. Annual Reviews of Immunology 2003;21:713-758.
  • Tau G, von der Weid T, Lu B, Cowan S, Kvatyuk M, Pernis A, Cattoretti G, Braunstein N, Coffman R, Rothman P. Interferon Signaling Alters the function of T helper Type 1 cells. J. Exp. Med. 2000;192(7): 977-986.
  • Williams MS, Kwon J. T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic Biol Med. 2004, 37: 1144-51.
  • Woodland DL, Dutton RW: Heterogeneity of CD4+ and CD8+ T cells. Current Opinion in Immunology 2003;15:354-361.

 

      Capítulo 3. La respuesta humoral específica.

  • Akira S, Uematsu S, Takeuchi O. Pathogen Recognition and Innate Immunity. Cell. 2006; 124: 783-801.
  • Brenner S and Milstein C. Origin of antibody variation. Nature 1966;211: 242.
  • Goldsby R, Kindt T, Kuby J, Osborne B. Immunology Fifth Edition. New York.
  • Houndmills. 2002.
  • Noia JM and Neuberger MS. Molecular Mechanisms of Antibody Somatic Hypermutation. Annu Rev Biochem 2007;76:1.
  • Roitt I, Brostoff J, Male D. Immunology (5th Ed.). London, Mosby, 1998.

 

      Capítulo 4. Inmunidad mediada por células.

  • Abbas A, et al. Inmunología Celular y Molecular. 2004. Elsevier.
  • Akira S, Uematsu S, Takeuchi O. Pathogen Recognition and Innate Immunity. Cell. 2006;124:783-801.
  • Goldsby RA, Kuby J. Inmunología. 2005. Mc Graw Hill.
  • Golubs ES. The cellular basic of the inmmune respnse. 2en Ed. Sinauer, Sunderland, Massachussetts 1981.
  • McCullough K, Summerfield A. Basic Concepts of Immune Response and Defense Development. Journal ILAR. 2005;46(3): 230–240.
  • Oppenheim JJ, Rosenstrich DL, Potter M. Cellular Functions in Immunity and inflammation. Arnold, London 1981.
  • Samelson LE: Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annual Reviews of Immunology 2002; 20:371-394.

 

      Capítulo 5. Citocinas.

  • Aguzzi A, Heikenwalder M. Prions, cytokines, and chemokines: a meeting in lymphoid organs. Immunity. 2005;22:145-54.
  • Belardelli F. Role of interferons and other cytokines in the regulation of immunity response. 1995;103: 1-6. 161-179.
  • Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005, 5: 521-31.
  • Gosain A, Gamelli RL. A primer in cytokines. J Burn Care Rehabil. 2005,26: 7-12.
  • Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G and Steinkasserer A. 2001. Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta. J Immunol 167(4): 1989-1995.
  • Lee M, Lee M, Lee S, Son M, Cho S, Park S, Kim H. Expression of Th1 and Th2 Type Cytokines Responding to HBsAg and HBxAg in Chronic Hepatitis B
  • Patients. J. Korean. Med. Sci. 1999;14: 175-181.
  • Moser B, Willimann K. Chemokines: role in inflammation and immune surveillance. Ann Rheum 2004, 6: 84-89.
  • Ohsuzu F. The roles of cytokines, inflammation and immunity in vascular diseases. J Atheroscler Thromb. 2004, 11: 313-21.
  • Raison CL, Capuron L, Miller A.H. Cytokines sing the blues: Inflammation and the pathogenesis of major depression. Trend Immunol. 2006;27:24-31.
  • Schindler H, Lutz MB, Rollinghoff M and Bogdan C. 2001. The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J Immunol 166(5): 3075-3082.
  • Tau G, von der Weid T, Lu B, Cowan S, Kvatyuk M, Pernis A, Cattoretti G, Braunstein N, Coffman R, Rothman P. 2000. Interferon _ Signaling Alters the function of T helper Type 1 cells. J. Exp. Med. 2000;192(7): 977-986.
  • Wang J, Wakeham J, Harkness R and Xing Z. 1999. Macrophages are a significant source of type 1 cytokines during mycobacterial infection. J Clin Invest 103(7): 1023-1029.

 

      Capítulo 6.  El complemento.

  • Asencio LP. Importancia del sistema de complemento. Rev Med Vallejiana. 2007; 4(1):2-10.
  • Botto M, Kirschfink M, Macor P, Pickering MC, Würzner R, Tedesco F. Complement in human diseases: Lessons from complement deficiencies. Mol. Immunol.2009;46, 14, 2774-2783.
  • Brown EJ, Joiner KA, Frank MM. Complement. In: Paul WE, editor. Fundamental Immunology. 3th ed. Raven Press: New York; 1985. p. 645-647.
  • Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol. 2004;5: 981-6.
  • Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol. 2009; 5: 981-6.
  • Cruse JM, Lewis RE. The complement system: Chronology and Mystique. In: Cruse JM, Lewis RE, editors. Complement profiles. Vol 1. Karger; 1993. p. 1-4.
  • Delgado Cervino E, Fontan G, López Trascasa M. C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect. Mol Immunol. 2007; 42:105-11.
  • Epstein, J., Eichbaum, Q., Sheriff, S., and Ezekowitz, R.A.B.:The collectins in innate immunity. Current Opinion in Immunology,1997; 8:29-35.
  • Frank MM. Complement in the pathophysiology of human disease. New Eng J Med 1987;316:1525-1530.
  • Fujita T, Endo Y, Nonaka M. Primitive complement system--recognition and activation. Mol Immunol. 2004;4 1:103-11
  • Gregory LA, Thielens NM, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C. X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. J Biol Chem 2003;278:32157-32164.
  • Loos M. Antibody-independent activation of C1, the first component of complement. Ann Immunol Inst Pasteur 1982;133C:165-179.
  • Nonaka M, Yoshizaki F. Evolution of the complement system. Mol Immunol. 2004; 40: 897-902
  • Petry F, Loos M. Common silent mutations in all types of hereditary complement C1q deficiencies. Immunogenetics. 2006; 57:566-71.
  • Pío R. Control of complement activation by cancer cells and its implications in antibodymediated cancer immunotherapy. Immunology. 2006;25(3):173-187.
  • Rupert KL, Moulds JM, Yang Y, Arnett FC, Warren RW, Reveille JD, et al. The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes. J Immunol. 2005; 169:1570-8.
  • Schumaker VN, Zavodszky P, Poon PH. Activation of the first component of complement. Annu Rev Immunol 1987;5:21-42.
  • Yang Y, Chung EK, Zhou B, Lhotta K, Hebert LA, Birmingham DJ, et al. The intricate role of complement component C4 in human systemic lupus erythematosus. Curr Dir Autoimun. 2004;7:98-132.
  • Walport MJ. Complement. First of two parts. N Engl J Med. 2001;344:1058-66.

 

      Capítulo 7. La inflamación.

  • Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: How hot is the link?. Biochem Pharmacol. 2006;72:1605-21
  • Aderem A, Smith KD. A systems approach to dissecting immunity and inflammation. Semin Immunol. 2004;16: 55-67
  • Delves PJ, Martin SJ, Burton DR, Roit IM. Roitt's Essential Immunology (11th edición), Malden, MA: Blackwell Publishing, 2006.
  • Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infection and Immunity 2005;73:1907-16.
  • Gallin, JI. Inflammation. En: Paul, WE. (Ed.) Fundamental Immunology. Raven Press, New York, 1989: 721-733
  • Hawiger J. Innate immunity and inflammation: a transcriptional paradigm. Immunol. 2001 Res. 23: 99-109.
  • Larsen GL, Herison PM. Mediators of inflammation. Ann. Rev. Inmunol. 1983; 335.
  • Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing. 2005, 2: 8.
  • Majno G, Palade GE. Studies of inflammation: I. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. J Biophys Biochem Cytol 1961;11:571- 584.
  • McGeer PL, McGeer EG. Innate immunity, local inflammation, and degenerative disease. Sci Aging Knowledge Environ. 2002.
  • Muller WA. Leukocyte-endothelial cell interactions in the inflammatory response. Lab. Invest. 2002. 82: 521-533.
  • Patología Humana. Robbins. Ed. Elservier. 7ª Edición. 2004
  • Springer TA. Traffic signals for lymphocye circulation and and leukocyte migration: the multistep paradigm. Cell 1994;76:301- 306.
  • Underhill, D.M. y A. Ozinsky. Phagocytosis of microbes: complexity in action. Annu. Rev.. Immunol.2002;20: 825-852.

 

      Capítulo 8. Regulación del sistema inmune.

  • Ader, R., Cohen, N., Felten, D. Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet 1995;345, 99-103.
  • Besedovsky HO, del Rey A. Immune-neuro-endocrine interactions: Facts and hypotheses. Endocr Rev. 1996;17:64-102.
  • Dafny N, Prieto-Gómez B, Reyes-Vázquez C. Does the immune system communicate with the central nervous system? Interferon modifies central nervous activity. J. Neuroimmunol. 1985; 9, 1-12.
  • Karim M, Bushell AR Wood KJ. Current. Opin. Immunol.; 2002, 14: 584.
  • Kindt T, Golsby R A, Osborne B A (2007)
  • Inmunología de Kuby. 6a Ed, Mc Graw Hill, México, pp 302-304.
  • Lapchak PA. A role for interleukin-2 in the regulation of striatal dopaminergic function. Neuroreport 1992;3, 165-168.
  • Macián F, García-Cózar F, Im SH, Horton HF, Byrne MC, Rao A. Transcriptional
  • mechanisms underlying lymphocyte tolerance. Cell 2002, 109:719.
  • McCullough K, Summerfield A. Basic Concepts of Immune Response and Defense Development. Journal ILAR. 2005;46(3):230–240.
  • Monjan, A.A. y Collector, M.I. Stress induced modulation of the immune response. Science 1977;196, 307-308
  • Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoides in stress and their relation to pharmacological actions. Endocr.Rev.1984; 5, 25-44.
  • Nance DM, Sanders V.M. Autonomic innervation and regulation of the immune system (1987–2007). Brain Behav Immun. 2007;21:736-45.
  • Regueiro JR, López Larrea C. Inmunología. Biología y Patología del Sistema Inmune (2ª Ed). Madrid, Editorial Médica Panamericana, 1997.

 

      Capítulo 9. Resumen: funcionamiento conjunto del sistema inmunologico.

  • Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. Philadelphia Ed. Saunders Elsevier 6th edition. 2007.
  • Bradley LM: Migration and T-lymphocyte effector function. Current Opinion in Immunology 2003;15: 343-348.
  • Bromsley SK, Burak WR, Jonson KG, Somersalo K, Sims TN, Davis MM, Shaw AAS, Allen PM, Dustin ML: The immunological synapse. Annual Reviews of Immunology 2001;375-396.
  • Fainboim L, Geffner J. Introducción a la inmunología humana. 5ª Edición. Argentina Editorial Panamericana. 2005.
  • Flajnik MF, L du Pasquier. Evolution of innate and adaptive immunity: can we draw a line? Trends in Immunology 2004; 25: 640-644.
  • Paul W (Editor): Fundamental Immunology, Lippincott Williams & Wilkins,
  • 1700 p, 2003.
  • Veillette A, Latour S, Davidson D: Negative regulation of immunoreceptor
  • signaling. Annual Review of Immunolgy 2002;20: 669-707.
  • Vivier E, Malissen B. Innate and adaptive immunity: specificities and signaling hierarchies revisited. Nat Immunol 2005; 6:17-21.